miR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth
نویسندگان
چکیده
منابع مشابه
miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth.
UNLABELLED miRNAs are a group of small, noncoding RNAs that modulate the translation of genes by binding to specific target sites in the target mRNA. This study investigated the biologic function and molecular mechanism of miR-21 in human cholangiocarcinoma. In situ hybridization analysis of human cholangiocarcinoma specimens showed increased miR-21 in cholangiocarcinoma tissue compared with th...
متن کاملChromatin, Gene and RNA Regulation miR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth
miRNAs are a group of small, noncoding RNAs that modulate the translation of genes by binding to specific target sites in the target mRNA. This study investigated the biologic function andmolecular mechanism of miR-21 in human cholangiocarcinoma. In situ hybridization analysis of human cholangiocarcinoma specimens showed increased miR-21 in cholangiocarcinoma tissue compared with the noncancero...
متن کاملOmega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression.
Prostaglandin E2 (PGE2) is a proinflammatory lipid mediator that promotes cancer growth. The 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes oxidation of the 15(S)-hydroxyl group of PGE2, leading to its inactivation. Therefore, 15-PGDH induction may offer a strategy to treat cancers that are driven by PGE2, such as human cholangiocarcinoma. Here, we report that omega-3 polyunsaturated...
متن کاملMiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN
Intrahepatic cholangiocarcinoma (ICC) constitutes the second-most common primary hepatic malignancy. MicroRNAs (miRNAs) play important roles in the pathogenesis of ICC. However, the clinical significance of miR-21 levels in ICC remains unclear. Here, we investigated the role of miR-21 in ICC and found that its expression was significantly upregulated in serum of ICC patients. Serum miR-21 level...
متن کاملω-3 Polyunsaturated Fatty Acids Up-regulate the Expression of 15-PGDH by Inhibiting miR-26a and miR-26b in Human Cholangiocarcinoma Cells
Running Title: ω-3 PUFAs up-regulate the expression of 15-PGDH in cholangiocarcinoma Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Yao et al ω-3 PUFAs up-regulate the expression of 15-PGDH by inhibiting miR-26a/b ABSTRACT Prostaglandins E 2 (PGE 2) is a pro-inflammatory and pro-tumorigenic lipid mediator that promotes cholangiocarcinoma gr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2014
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-13-0419